Rearrangement of Side Chains in the Catalytic Site
Opening Image: AMP-PNP at the catalytic site of F1-ATPase. The Mg2+ is shown in lime green.
to spacefill AMP-PNP, an analog of ATP in which the oxygen atom between the β and γ phosphates is replaced by a nitrogen atom.
In the previous tutorial we saw that the conformations of βT and βR are vastly different. We might expect that the side chains at the catalytic site are arranged differently in the two states, and this is the case.